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KMID : 0360220120530040499
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Journal of the Korean Ophthalmological Society
2012 Volume.53 No. 4 p.499 ~ p.504
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Prevalence and Clinical Aspects of Sjogren Syndrome in Dry Eye Patients
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Lee Jun-Sung
Choi Won
Lee Shin-Seok
Yoon Kyung-Chul
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Abstract
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Purpose: To investigate the prevalence and clinical aspects of Sjogren syndrome in patients who were diagnosed with dry eye syndrome in Korea.
Methods: The medical records of patients who were diagnosed with dry eye syndrome in a dry eye clinic during a 2-year period (March 2008 to March 2010) and were followed up for more than 3 months were reviewed retrospectively.
Results: A total of 206 patients were included in the present study. Fifty-eight patients (28%) had Sjogren syndrome and 39 patients (19%) showed primary Sjogren syndrome. Sjogren syndrome patients showed poorer results than non-Sjogren syndrome patients in ocular surface disease index score (OSDI), tear break up time, Schirmer test score, and ocular surface staining score using the Oxford scheme (p < 0.05). Among the patients with primary Sjogren syndrome, 27 patients were SSA (anti-Ro antibodies) or SSB (anti-La antibodies) positive and 12 patients were sero-negative. There were no statistically significant differences in objective or subjective parameters between the sero-positive and sero-negative groups.
Conclusions: Sjogren syndrome was observed in 28% of all dry eye patients, in two-thirds of severe dry eye patients. Sjogren syndrome patients showed more severe clinical aspects than dry eye patients with non-Sjogren syndrome.
Diagnosing Sjogren syndrome through systemic evaluation is necessary in the patients with severe dry eye.
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KEYWORD
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Autoantibodies, Dry eye, Prevalence, Sjogren syndrome
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